Phenylpropanoids and polyketides
Medchemexpress LLC Palomid 529 | 914913-88-5 | 99.4% | C24H22O6 | 50 MG
Palomid 529 | 914913-88-5 | 99.4% | C24H22O6 | 50 MG
Medchemexpress LLC 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)- | 480-36-4 | 592.55 | 20 MG
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). It exhibits various activities including anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial, and antiviral properties. Linarin can be utilized in the study of diseases affecting the nervous system, osteoporosis, and cancer.
- Orally active and selective inhibitor of acetylcholinesterase (AChE).
- Anti-inflammatory properties.
- Antioxidant properties.
- Sleep aid and sedation.
- Promotes bone differentiation.
- Anti-tumor activity.
- Antibacterial properties.
- Antiviral properties.
- Useful for studying diseases such as those of the nervous system, osteoporosis, and cancer.
Medchemexpress LLC 4-Methylesculetin | 529-84-0 | 1 ML
4-Methylesculetin is an orally active coumarin derivative known for its potent antioxidant and anti-inflammatory properties. It demonstrates inhibitory effects on myeloperoxidase activity and offers protection against bone resorption by decreasing elevated levels of bone-joint exoglycosidases, cathepsin-D, and tartrate resistant acid phosphatases. This compound also helps ameliorate upregulated non-enzymatic inflammatory markers such as TNF-α, IL-1β, IL-6, COX-2, and PGE2, making it a promising subject for inflammatory disease research.
- Orally active coumarin derivative
- Potent antioxidant and anti-inflammatory activities
- Inhibits myeloperoxidase activity
- Protects against bone resorption
- Ameliorates upregulated non-enzymatic inflammatory markers
- Promising for research on inflammatory diseases
Apexbio Technology LLC Esculin 531-75-9 20mg
Esculin (CAS 531-75-9) is a coumarin glucoside isolated from the bark of Aesculus hippocastanum It functions primarily as a -glucosidase substrate hydrolyzing to esculetin and glucose upon enzymatic action Esculin s fluorescence properties make it valuable in assays monitoring -glucosidase activity in microbiological and biochemical research Additionally its antioxidant and vasoprotective effects have supported investigations into microcirculatory disorders and oxidative stress-related models Esculin is soluble in hot ethanol methanol pyridine ethyl acetate and acetic acid and should be stored in sealed cool and dry conditions
TARGETMOL CHEMICALS INC ML-090 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2 NOX3 NOX4 (all IC50s >10 uM). purity: 98%
Apexbio Technology LLC (5Z)-7-Oxozeaenol(Synonyms: (5Z)-7-Oxozeaenol, 7-Oxozeaenol, TAK1 inhibitor, MAPKKK inhibitor), 1mg, CAS: 253863-19-3.
(5Z)-7-Oxozeaenol (CAS 253863-19-3) is a naturally occurring resorcylic lactone obtained from fungal sources It functions as a selective inhibitor of transforming growth factor -activated kinase 1 (TAK-1) a member of the mitogen-activated protein kinase kinase kinase (MAPKKK) family In biochemical assays (5Z)-7-Oxozeaenol inhibits purified TAK-1 with an IC50 of approximately 8 1 nM exhibiting minimal activity against related MAPKKKs Cellular studies indicate irreversible blockade of IL-1-stimulated TAK-1 NF- B and JNK/p38 signaling pathways This molecule is useful in inflammation research as demonstrated by its suppression of IL-1-induced COX-2 production and attenuation of inflammatory responses in mouse models
Apexbio Technology LLC Zearalenone(Synonyms: F-2 toxin, Mycotoxin F2, Zearalenolactone, RAL, ZEA, Zenon), 5mg, CAS: 17924-92-4.
Zearalenone (CAS 17924-92-4) is a mycotoxin produced primarily by Fusarium fungi frequently contaminating feed and food products It exhibits estrogenic activity through interaction with estrogen receptors thus altering endocrine signaling pathways Although acutely low in toxicity zearalenone effectively modulates estrogen receptor-mediated responses influencing hormonal balance in livestock species such as pigs cattle and sheep In biomedical research zearalenone serves as a tool compound to study estrogen receptor-mediated mechanisms and endocrine disruption particularly in young animals within veterinary pharmacological contexts
Medchemexpress LLC 5Z-7-Oxozeaenol | 253863-19-3 | 99.3% | 10 MG
5Z-7-Oxozeaenol is a natural anti-protozoan compound of fungal origin, serving as a potent, irreversible, and selective inhibitor of TAK1 and VEGF-R2, with IC50 values of 8 nM and 52 nM, respectively.
- Potent, irreversible, and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 (TAK1, IC50: 8.1 nM).
- Less active on MEK1 (IC50: 411 nM).
- Prevents inflammation by inhibiting TAK1 MAPK kinase kinase catalytic activity.
- Inhibitor of VEGF-R2 (IC50: 52 nM).
- Also inhibits VEGF-R3 (IC50: 110 nM), FLT3 (IC50: 170 nM), PDGFR-β (IC50: 340 nM), B-RAF VE (IC50: 6300 nM), and SRC (IC50: 6600 nM).
- Inhibits JNK/p38 pathway (signal-specific, not a direct inhibitor).
- Suppresses PMA-induced AP-1 activity in KT cells; no effect on IL-1-induced NF-kB activity in KK cells.
Medchemexpress LLC 14,15-EE-5(Z)-E | 519038-92-7 | >98.0% | 25 UG
14,15-EE-5(Z)-E is a structural analogue of 14,15-epoxide dicartrienoic acid (14,15-EET) that antagonizes EET-induced relaxation of vascular smooth muscle. It is used as a biochemical probe in cardiovascular research to study EET-mediated signaling.
- Structural analogue of 14,15-epoxide dicartrienoic acid (14,15-EET).
- Antagonizes EET-induced relaxation of vascular smooth muscle.
- Molecular formula: C20H36O3; molecular weight: 324.50.
- CAS number: 519038-92-7.
- Purity typically ≥98% (supplier reported).
- Storage: solution, -20°C, up to 2 years.
- Common use: probe in cardiovascular and vascular physiology research.
Cayman Chemical 5Z 2E-CU-3 25mg
A DGK-α inhibitor (IC50 = 0.6 µM for the porcine enzyme); selective for DGK-α over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM); induces apoptosis in HeLa and HepG2 cells and enhances concanavalin A-induced increases in IL2 mRNA expression in Jurkat T cells at 5 µM
Cayman Chemical 5Z 2E-CU-3 10mg
A DGK-α inhibitor (IC50 = 0.6 µM for the porcine enzyme); selective for DGK-α over other type I DGKs, as well as type II, type III, type IV, and type V DGKs (IC50s = 7-36 µM); induces apoptosis in HeLa and HepG2 cells and enhances concanavalin A-induced increases in IL2 mRNA expression in Jurkat T cells at 5 µM
Cayman Chemical 5Z-7-Oxozeaenol 1mg
A TAK1 inhibitor (IC50 = 8.1 nM in the presence of TAB1); selective for TAK1 over MEK1 and MEKK1 (IC50s = 411 and 268 nM, respectively), as well as ASK1 and IKKβ at 300 nM; inhibits NF-κB activity in a reporter assay using HEK293 cells expressing TAK1 and TAB1 (IC50 = 83 nM); reduces IL-1-induced increases in COX-2 levels in MEFs; sensitizes HeLa cells to TRAIL-induced apoptosis at 300 nM; induces necroptosis when used in combination with TNF and zVAD in primary mouse BMDMs at 100 nM; topical application prevents picryl chloride-induced increases in EAr thickness in mice